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Use Only as Prescribed – Follow your doctor’s instructions carefully to avoid overdose or dependence. Avoid Mixing with Alcohol & Other Depressants – Combining Demerol with alcohol, benzodiazepines, or other opioids can cause dangerous breathing problems. Short-Term Use Only – Demerol is not recommended for long-term pain management due to the risk of seizures and toxicity from its metabolite, normeperidine. Watch for Side Effects – Common side effects include dizziness, drowsiness, nausea, and confusion. Seek medical help if you experience trouble breathing or severe drowsiness. Risk of Dependence & Withdrawal – If taken regularly, stopping suddenly can lead to withdrawal symptoms like sweating, shaking, and anxiety. Taper off under a doctor's guidance. Safer Alternatives Exist – Other opioids like oxycodone or non-opioid pain relievers are often preferred for long-term pain control.