What is oxycodone? Oxycodone is a prescription medicine used to treat moderate to severe pain when other pain medicines do not work well enough or are not tolerated. Oxycodone is an opioid pain medication, sometimes called a narcotic, that works by activating opioid receptors in the nervous system. Oxycodone is a controlled substance, Schedule II, meaning it has a high potential for abuse. Oxycodone can be used for acute (short-term) pain, and the extended-release tablets are used around the clock to treat severe and chronic pain that requires longer treatment. Extended-release products should not be used for as-needed pain relief. Oxycodone is available as: immediate-release tablets: oxycodone 5 mg, 10 mg, 15 mg, 20 mg and 30 mg immediate-release, abuse-deterrent tablet: oxycodone 10 mg immediate-release capsules: oxycodone 5 mg immediate-release oral solution: oxycodone 5 mg per 5 mL (1 mg/mL), 100 mg per 5 mL (20 mg/mL) extended-release tablets: oxycodone 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, and 80 mg. Oxycodone should only be used for an extended time if the pain remains severe enough to require an opioid analgesic and other treatment options continue to be inadequate. Oxycodone brand names include OxyContin, Roxicodone, RoxyBond, Xtampza ER, and Oxaydo. 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